P-Stereogenic PCP pincer-Pd complexes: synthesis and application in asymmetric addition of diarylphosphines to nitroalkenes

Boqiang Ding; Zhenfeng Zhang; Yang Xu; Yangang Liu; Masashi Sugiya; Tsuneo Imamoto; Wanbin Zhang

doi:10.1021/ol402627f

P-Stereogenic PCP pincer-Pd complexes: synthesis and application in asymmetric addition of diarylphosphines to nitroalkenes

Org Lett. 2013 Nov 1;15(21):5476-9. doi: 10.1021/ol402627f. Epub 2013 Oct 21.

Authors

Boqiang Ding¹, Zhenfeng Zhang, Yang Xu, Yangang Liu, Masashi Sugiya, Tsuneo Imamoto, Wanbin Zhang

Affiliation

¹ School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University , 800 Dongchuan Road, Shanghai 200240, P. R. China , School of Pharmacy, Shanghai Jiao Tong University , 800 Dongchuan Road, Shanghai 200240, P. R. China , Organic R&D Department, Nippon Chemical Industrial Co., Ltd. , Kameido, Koto-ku, Tokyo 136-8515, Japan , and Department of Chemistry, Graduate School of Science, Chiba University , Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

PMID: 24144229
DOI: 10.1021/ol402627f

Abstract

Novel P-stereogenic PCP pincer-Pd complexes were designed and prepared in short steps from optically pure tert-butylmethylphosphine-borane. These optically active Pd-complexes were successfully applied in asymmetric addition of diarylphosphines to nitroalkenes with high yields and good enantioselectivity.