Abstract
A new arenetelluronic triorganotin ester, namely (Me3Sn)4[o-Me-PhTe(μ-O)(OH)O2)]2 (1) has been prepared by the reaction of o-tolyltelluronic acid and Me3SnCl in the presence of potassium hydroxide. The complex was fully characterized by elemental analysis, FT-IR, NMR ((1)H, (13)C, (119)Sn) spectroscopy and X-ray crystallography. Structure analysis revealed that the complex crystallized as Sn4Te2 units and a 1D linear chain was formed by intermolecular C-HO interactions. Cytotoxic assessments showed that the complex can induce apoptotic cell death via accumulation of ROS, collapse of the MMP and activating caspase-3. The results indicated that ROS is crucial to the cytotoxicity induced by the complex.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Apoptosis / drug effects
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Caspase 3 / metabolism
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Chemistry Techniques, Synthetic
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Coordination Complexes / chemistry*
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Enzyme Activation / drug effects
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Humans
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Intracellular Space / drug effects
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Intracellular Space / metabolism
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Matrix Metalloproteinases / metabolism
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Membrane Potential, Mitochondrial / drug effects
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Models, Molecular
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Molecular Conformation
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Reactive Oxygen Species / metabolism
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Tin / chemistry*
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Trimethyltin Compounds / chemical synthesis*
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Trimethyltin Compounds / chemistry
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Trimethyltin Compounds / pharmacology*
Substances
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Antineoplastic Agents
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Coordination Complexes
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Reactive Oxygen Species
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Trimethyltin Compounds
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trimethyltin
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Tin
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Caspase 3
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Matrix Metalloproteinases