Abstract
A novel and efficient method for the preparation of antiviral nucleoside 5'-H-phosphonamidates has been developed. The oxidization of the H-phosphonamidate intermediates with iodine and sulfur afforded nucleoside 5'-phosphoramidates and 5'-thiophosphoramidates in high yields.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amides / chemical synthesis*
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Amides / chemistry
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / chemistry
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Magnetic Resonance Spectroscopy
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Nucleosides / chemical synthesis*
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Nucleosides / chemistry
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Organothiophosphorus Compounds / chemical synthesis*
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Organothiophosphorus Compounds / chemistry
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Phosphoric Acids / chemical synthesis*
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Phosphoric Acids / chemistry
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Prodrugs / chemical synthesis*
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Prodrugs / chemistry
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Pyrimidine Nucleosides / chemical synthesis*
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Pyrimidine Nucleosides / chemistry
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Stavudine / chemical synthesis
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Stavudine / chemistry
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Zidovudine / chemical synthesis
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Zidovudine / chemistry
Substances
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Amides
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Antiviral Agents
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Nucleosides
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Organothiophosphorus Compounds
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Phosphoric Acids
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Prodrugs
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Pyrimidine Nucleosides
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Zidovudine
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phosphoramidic acid
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Stavudine