Changes in oxidant and antioxidant status of females with experimental gestosis under the effect of GABA derivatives

I N Tyurenkov; V N Perfilova; T A Popova; L B Ivanova; I I Prokofiev; O V Gulyaeva; L I Stepa

doi:10.1007/s10517-013-2154-9

Changes in oxidant and antioxidant status of females with experimental gestosis under the effect of GABA derivatives

Bull Exp Biol Med. 2013 Jul;155(3):363-5. doi: 10.1007/s10517-013-2154-9.

Authors

I N Tyurenkov¹, V N Perfilova, T A Popova, L B Ivanova, I I Prokofiev, O V Gulyaeva, L I Stepa

Affiliation

¹ Department of Pharmacology and Biopharmacy, Faculty for Advanced Medical Training, Institute of Pharmacology, Volgograd State Medical University, Russia. vnperfilova@mail.ru.

PMID: 24137604
DOI: 10.1007/s10517-013-2154-9

Abstract

Experimental gestosis, modeled by replacement of drinking water with 1.8% NaCl solution, induced oxidative stress, which was seen from accumulation of MDA (secondary LPO product) and inhibition of SOD and glutathione peroxidase in the brain, liver, and uterus of animals with gestosis. Citrocard and saliphene (GABA derivatives) inhibited LPO (reduced MDA concentrations in the studied organs) and activated antioxidant enzymes in experimental gestosis.

MeSH terms

Animals
Female
Glutathione Peroxidase / antagonists & inhibitors
Lipid Peroxidation / drug effects
Lipid Peroxidation / physiology
Oxidative Stress / drug effects*
Pre-Eclampsia / chemically induced
Pre-Eclampsia / drug therapy*
Pregnancy
Rats
Sodium Chloride / adverse effects
Superoxide Dismutase / antagonists & inhibitors
gamma-Aminobutyric Acid / analogs & derivatives*
gamma-Aminobutyric Acid / pharmacology

Substances

Sodium Chloride
gamma-Aminobutyric Acid
Glutathione Peroxidase
Superoxide Dismutase
4-amino-3-phenylbutyric acid