Prospects of using benzodiazepines in complex therapy of poisonings with anticholinesterase agents

M A Yudin; S N Subbotina; V N Bykov; S V Chepur; A S Nikiforov

doi:10.1007/s10517-013-2152-y

Prospects of using benzodiazepines in complex therapy of poisonings with anticholinesterase agents

Bull Exp Biol Med. 2013 Jul;155(3):354-9. doi: 10.1007/s10517-013-2152-y.

Authors

M A Yudin¹, S N Subbotina, V N Bykov, S V Chepur, A S Nikiforov

Affiliation

¹ Research Testing Institute of Military Medicine of S. M. Kirov Military Medical Academy, St. Petersburg, Russia. mihei_bridge@mail.ru.

PMID: 24137602
DOI: 10.1007/s10517-013-2152-y

Abstract

The efficiency of benzodiazepines on mouse model of anticholinesterase poisoning was shown. The protective effects of clonazepam and midazolam were observed at high (1 TD50, incoordination) and medium (0.3 TD50) doses and the effects of phenazepam and diazepam were found only at high doses. Midazolam produced the most pronounced protective effect: administration of this drug significantly increased the protective index of atropine+HI-6 combination during poisoning.

MeSH terms

Animals
Atropine
Benzodiazepines / pharmacology
Benzodiazepines / therapeutic use*
Cholinesterase Inhibitors / administration & dosage
Cholinesterase Inhibitors / poisoning*
Clonazepam / pharmacology
Diazepam / pharmacology
Dose-Response Relationship, Drug
Injections, Intramuscular
Male
Mice
Midazolam / pharmacology
Oximes
Pyridinium Compounds
Statistics, Nonparametric
Toxicity Tests

Substances

Cholinesterase Inhibitors
Oximes
Pyridinium Compounds
Benzodiazepines
phenazepam
Clonazepam
Atropine
asoxime chloride
Diazepam
Midazolam