Photosensitization of singlet oxygen and in vivo photodynamic therapeutic effects mediated by PEGylated W(18)O(49) nanowires

Angew Chem Int Ed Engl. 2013 Nov 18;52(47):12332-6. doi: 10.1002/anie.201307358. Epub 2013 Oct 18.

Abstract

Upon excitation with near-infrared light (980 nm), PEGylated W18 O49 nanowires can sensitize the formation of singlet oxygen and thus reactive oxygen species (ROS). The resulting photodynamic therapy (PDT) effect can cause the destruction of tumors in the absence of organic photosensitizers. PEG=poly(ethylene glycol), PTT=photothermal therapy.

Keywords: nanowires; photodynamic therapy; photothermal therapy; reactive oxygen species; singlet oxygen.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibiotics, Antineoplastic / chemistry
  • Antibiotics, Antineoplastic / pharmacology
  • Antibiotics, Antineoplastic / therapeutic use
  • Cell Survival / drug effects
  • Doxorubicin / chemistry
  • Doxorubicin / pharmacology
  • Doxorubicin / therapeutic use
  • HeLa Cells
  • Humans
  • Infrared Rays
  • Melanoma, Experimental / drug therapy
  • Mice
  • Mice, Inbred C57BL
  • Nanowires / chemistry*
  • Nanowires / therapeutic use
  • Oxides / chemistry*
  • Photochemotherapy
  • Photosensitizing Agents / chemistry*
  • Photosensitizing Agents / pharmacology
  • Photosensitizing Agents / therapeutic use
  • Polyethylene Glycols / chemistry*
  • Singlet Oxygen / chemistry
  • Singlet Oxygen / metabolism*
  • Sodium Azide / chemistry
  • Sodium Azide / pharmacology
  • Temperature
  • Transplantation, Heterologous
  • Tungsten / chemistry*

Substances

  • Antibiotics, Antineoplastic
  • Oxides
  • Photosensitizing Agents
  • Singlet Oxygen
  • Polyethylene Glycols
  • Doxorubicin
  • tungsten oxide
  • Sodium Azide
  • Tungsten