Incorporation by coordination and release of the iron chelator drug deferiprone from zinc-based metal-organic frameworks

Chem Commun (Camb). 2013 Dec 14;49(96):11260-2. doi: 10.1039/c3cc45689g.

Abstract

A series of new zinc-based metal-organic framework materials has been prepared in which deferiprone is incorporated as a chelating ligand on infinite or tri-zinc secondary building units following deprotonation. Deferiprone is immediately released from the MOFs on treatments with 1 N hydrochloric acid or buffer, but slow release is observed in ethanoic acid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Coordination Complexes / chemistry*
  • Deferiprone
  • Delayed-Action Preparations / chemistry*
  • Iron Chelating Agents / administration & dosage*
  • Iron Chelating Agents / chemistry
  • Models, Molecular
  • Pyridones / administration & dosage*
  • Pyridones / chemistry
  • Zinc / chemistry*

Substances

  • Coordination Complexes
  • Delayed-Action Preparations
  • Iron Chelating Agents
  • Pyridones
  • Deferiprone
  • Zinc