Determination of the biodistribution and dosimetry of ¹²³I-FP-CIT in male patients with suspected Parkinsonism or Lewy body dementia using planar and combined planar and SPECT/CT imaging

Appl Radiat Isot. 2013 Dec:82:300-7. doi: 10.1016/j.apradiso.2013.09.006. Epub 2013 Sep 27.

Abstract

In this study, (123)I-FP-CIT biodistribution and dosimetry was determined in 10 adult male patients using planar gamma camera imaging alone or in combination with single photon emission computed tomography /X-ray computed tomography (SPECT/CT) imaging. Dosimetric assessment using planar plus SPECT/CT imaging resulted in significantly different estimates of organ-absorbed doses compared to estimates based on planar imaging alone. We conclude that the use of complementary SPECT/CT measurements in biodistribution studies is valuable for determining the organ doses more accurately.

Keywords: (123)I-FP-CIT; Biokinetics; Dosimetry; Lewy body dementia; Parkinson's disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Humans
  • Iodine Radioisotopes* / pharmacokinetics
  • Lewy Body Disease / diagnostic imaging*
  • Male
  • Middle Aged
  • Parkinsonian Disorders / diagnostic imaging*
  • Radiometry
  • Radiopharmaceuticals* / pharmacokinetics
  • Tissue Distribution
  • Tomography, Emission-Computed, Single-Photon
  • Tomography, X-Ray Computed
  • Tropanes* / pharmacokinetics

Substances

  • Iodine Radioisotopes
  • Radiopharmaceuticals
  • Tropanes
  • 2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane