Endogenous 4β-hydroxycholesterol-to-cholesterol ratio is not a validated biomarker for the assessment of CYP3A activity

Drug Metab Dispos. 2013 Nov;41(11):1972. doi: 10.1124/dmd.113.054361.

Authors

Joseph D Ma¹, Anne N Nafziger, Joseph S Bertino Jr

Affiliation

¹ Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California (J.D.M.); and Bertino Consulting, Schenectady, New York (A.N.N., J.S.B.).

PMID: 24131962
DOI: 10.1124/dmd.113.054361

No abstract available

Publication types

Letter
Comment

MeSH terms

Cytochrome P-450 CYP3A / biosynthesis*
Female
Humans
Hydroxycholesterols / metabolism*
Male
Midazolam / pharmacokinetics*
Rifampin / pharmacology*

Substances

Hydroxycholesterols
Cytochrome P-450 CYP3A
Midazolam
Rifampin