Effect of pegylated hyaluronate-endo-β-N-acetylhexosaminidase on humoral mechanisms regulating the functions of progenitor cells during chronic hepatitis

Bull Exp Biol Med. 2013 Jun;155(2):179-82. doi: 10.1007/s10517-013-2106-4.

Abstract

We studied the effect of hyaluronate-endo-β-N-acetylhexosaminidase on the secretory function of the liver and bone marrow microenvironment cells in chronic hepatitis. Enhanced production of substances stimulating parenchymal tissue-specific precursors and stem cell homing factors by liver cells was revealed. At the same time, production of SDF-1 and other chemoattractants and adhesion factors of progenitor cells by bone marrow elements was reduced.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bone Marrow Cells / drug effects
  • Bone Marrow Cells / metabolism*
  • Cell Movement / drug effects
  • Cellular Microenvironment / drug effects
  • Chemokine CXCL12 / biosynthesis*
  • Hepatitis, Chronic / metabolism*
  • Hyaluronoglucosaminidase
  • Liver / cytology
  • Liver / drug effects
  • Liver / metabolism*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Polyethylene Glycols / pharmacology*
  • Stem Cells / drug effects*
  • Stem Cells / metabolism
  • beta-N-Acetylhexosaminidases / pharmacology*

Substances

  • CXCL12 protein, rat
  • Chemokine CXCL12
  • Polyethylene Glycols
  • Hyaluronoglucosaminidase
  • beta-N-Acetylhexosaminidases
  • pegylated hyaluronate-endo-beta-N-acetylhexosaminidase