Abstract
We studied the effect of hyaluronate-endo-β-N-acetylhexosaminidase on the secretory function of the liver and bone marrow microenvironment cells in chronic hepatitis. Enhanced production of substances stimulating parenchymal tissue-specific precursors and stem cell homing factors by liver cells was revealed. At the same time, production of SDF-1 and other chemoattractants and adhesion factors of progenitor cells by bone marrow elements was reduced.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Bone Marrow Cells / drug effects
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Bone Marrow Cells / metabolism*
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Cell Movement / drug effects
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Cellular Microenvironment / drug effects
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Chemokine CXCL12 / biosynthesis*
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Hepatitis, Chronic / metabolism*
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Hyaluronoglucosaminidase
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Liver / cytology
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Liver / drug effects
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Liver / metabolism*
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Male
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Mice
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Mice, Inbred C57BL
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Polyethylene Glycols / pharmacology*
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Stem Cells / drug effects*
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Stem Cells / metabolism
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beta-N-Acetylhexosaminidases / pharmacology*
Substances
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CXCL12 protein, rat
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Chemokine CXCL12
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Polyethylene Glycols
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Hyaluronoglucosaminidase
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beta-N-Acetylhexosaminidases
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pegylated hyaluronate-endo-beta-N-acetylhexosaminidase