New pterosin sesquiterpenes and antitubercular constituents from Pteris ensiformis

Chem Biodivers. 2013 Oct;10(10):1903-8. doi: 10.1002/cbdv.201300072.

Abstract

Two new pterosin sesquiterpenes, (2S)-13-hydroxypterosin A (1) and (2S,3S)-12-hydroxypterosin Q (2), were isolated from the whole plants of Pteris ensiformis, together with six known compounds. The structures of 1 and 2 were determined through extensive 1D/2D-NMR and MS analyses. Compound 2 exhibited antitubercular activity (MIC 6.25 μg/ml) against Mycobacterium tuberculosis H37 Rv in vitro.

Keywords: Antitubercular activity; Pteris ensiformis; Pterosin sesquiterpenes; Sesquiterpenes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antitubercular Agents* / chemistry
  • Antitubercular Agents* / isolation & purification
  • Antitubercular Agents* / pharmacology
  • Indans / chemistry*
  • Magnetic Resonance Spectroscopy
  • Microbial Sensitivity Tests
  • Molecular Conformation
  • Mycobacterium tuberculosis / drug effects*
  • Plant Extracts* / chemistry
  • Plant Extracts* / pharmacology
  • Pteris / chemistry*
  • Pteris / metabolism
  • Sesquiterpenes / chemistry*
  • Sesquiterpenes / isolation & purification
  • Sesquiterpenes / pharmacology*

Substances

  • 12-hydroxypterosin Q
  • Antitubercular Agents
  • Indans
  • Plant Extracts
  • Sesquiterpenes
  • pterosin