Pd(II)-catalyzed direct C-H acylation of N-Boc hydrazones with aldehydes: one-pot synthesis of 1,2-diacylbenzenes

Abstract

A palladium(II)-catalyzed direct acylation of acetophenone N-Boc hydrazones with aldehydes via C-H bond activation is described. This protocol provides direct access to a range of 1,2-diacylbenzenes, which are useful precursors to construct biologically interesting and pharmaceutically important compounds.