Dendrimer space exploration: an assessment of dendrimers/dendritic scaffolding as inhibitors of protein-protein interactions, a potential new area of pharmaceutical development

Chem Rev. 2014 Jan 22;114(2):1327-42. doi: 10.1021/cr400362r. Epub 2013 Oct 15.

Authors

Serge Mignani¹, Saïd El Kazzouli, Mosto M Bousmina, Jean-Pierre Majoral

Affiliation

¹ Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques, CNRS UMR 8601, Université Paris Descartes, Sorbonne Paris Cité , 45 rue des Saints Pères, 75006 Paris, France.

PMID: 24127777
DOI: 10.1021/cr400362r

No abstract available

Publication types

Review

MeSH terms

Allosteric Regulation / drug effects
Dendrimers / chemistry
Dendrimers / pharmacology*
Drug Discovery*
Humans
Protein Binding / drug effects
Proteins / metabolism*
Small Molecule Libraries / chemistry
Small Molecule Libraries / pharmacology*
Structure-Activity Relationship

Substances

Dendrimers
Proteins
Small Molecule Libraries