DMSO-mediated ligand dissociation: renaissance for biological activity of N-heterocyclic-[Ru(η6-arene)Cl2] drug candidates

Chemistry. 2013 Oct 25;19(44):14768-72. doi: 10.1002/chem.201303341. Epub 2013 Oct 2.
No abstract available

Keywords: N-heterocycles; bioorganometallic chemistry; dimethyl sulfoxide; ligand exchange; ruthenium.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Coordination Complexes / chemistry*
  • Coordination Complexes / pharmacology*
  • Dimethyl Sulfoxide / chemistry*
  • Heterocyclic Compounds / chemistry*
  • Heterocyclic Compounds / pharmacology*
  • Humans
  • Ligands
  • Rats
  • Ruthenium / chemistry*
  • Ruthenium / pharmacology*

Substances

  • Coordination Complexes
  • Heterocyclic Compounds
  • Ligands
  • Ruthenium
  • Dimethyl Sulfoxide