Intraperitoneal chemotherapy (IPC) for peritoneal carcinomatosis: review of animal models

J Surg Oncol. 2014 Feb;109(2):110-6. doi: 10.1002/jso.23464. Epub 2013 Oct 12.

Abstract

The development of suitable animal models is essential to experimental research on intraperitoneal chemotherapy (IPC). This review of the English literature (MEDLINE) presents a detailed analysis of current animal models and gives recommendations for future experimental research. Special consideration should be given to cytotoxic drug dose and concentration, tumor models, and outcome parameters.

Keywords: HIPEC; animal experimentation; colorectal carcinoma; cytoreductive surgery; peritoneal metastasis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacokinetics
  • Chemotherapy, Cancer, Regional Perfusion / methods*
  • Disease Models, Animal
  • Hyperthermia, Induced / methods
  • Neoplasms, Experimental / drug therapy
  • Neoplasms, Experimental / surgery
  • Peritoneal Neoplasms / drug therapy*
  • Peritoneal Neoplasms / surgery

Substances

  • Antineoplastic Agents