The development of suitable animal models is essential to experimental research on intraperitoneal chemotherapy (IPC). This review of the English literature (MEDLINE) presents a detailed analysis of current animal models and gives recommendations for future experimental research. Special consideration should be given to cytotoxic drug dose and concentration, tumor models, and outcome parameters.
Keywords: HIPEC; animal experimentation; colorectal carcinoma; cytoreductive surgery; peritoneal metastasis.
© 2013 Wiley Periodicals, Inc.