Lack of association between the LPR and VNTR polymorphisms of the serotonin transporter gene and cocaine dependence in a Spanish sample

Psychiatry Res. 2013 Dec 30;210(3):1287-9. doi: 10.1016/j.psychres.2013.09.004. Epub 2013 Oct 8.

Abstract

We genotyped the LPR and VNTR polymorphisms of the serotonin transporter gene in 504 cocaine-dependent patients and 508 controls. No association was detected with either polymorphism or with any haplotype combination. This study provided no evidence that these polymorphisms confer susceptibility to cocaine dependence in our sample.

Keywords: 5HTT; Association study; Drug addiction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Case-Control Studies
  • Cocaine-Related Disorders / ethnology*
  • Cocaine-Related Disorders / genetics*
  • Genotype
  • Haplotypes
  • Humans
  • Male
  • Minisatellite Repeats / genetics*
  • Polymerase Chain Reaction / methods
  • Polymorphism, Genetic*
  • Serotonin Plasma Membrane Transport Proteins / genetics*
  • Spain
  • White People / ethnology
  • White People / genetics

Substances

  • SLC6A4 protein, human
  • Serotonin Plasma Membrane Transport Proteins