Local control of rhino-orbito-cerebral mucormycosis dramatically impacts survival

Clin Microbiol Infect. 2014 May;20(5):O336-9. doi: 10.1111/1469-0691.12408. Epub 2013 Nov 6.

Abstract

Surgery and antifungals are the reference standard for rhino-orbito-cerebral mucormycosis (ROCM) treatment. The impact of local control on survival of 22 consecutive ROCM adults was studied on day 90: none vs. 75% died, respectively, with or without local control (p <0.0001). Hence, repeated surgical procedures are recommended to achieve local control of ROCM.

Keywords: Local control; mucormycosis; necrosis; sinusitis; surgery.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antifungal Agents / therapeutic use
  • Bone Diseases, Infectious / microbiology
  • Bone Diseases, Infectious / mortality
  • Bone Diseases, Infectious / therapy*
  • Brain Diseases / microbiology
  • Brain Diseases / therapy
  • Combined Modality Therapy / methods
  • Debridement / methods*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Mucormycosis / mortality
  • Mucormycosis / therapy*
  • Orbital Diseases / microbiology
  • Orbital Diseases / mortality
  • Orbital Diseases / therapy*
  • Paranasal Sinus Diseases / microbiology
  • Paranasal Sinus Diseases / mortality
  • Paranasal Sinus Diseases / therapy*
  • Retrospective Studies
  • Skull Base / surgery
  • Survival Rate
  • Young Adult

Substances

  • Antifungal Agents