Abstract
A series of tubes: The continuous manufacture of a finished drug product starting from chemical intermediates is reported. The continuous pilot-scale plant used a novel route that incorporated many advantages of continuous-flow processes to produce active pharmaceutical ingredients and the drug product in one integrated system.
Keywords:
continuous processing; flow chemistry; lactones; protecting groups; synthetic methods.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acids / chemistry
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Amides / chemical synthesis
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Amides / chemistry
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Amides / isolation & purification
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Catalysis
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Crystallization
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Drug Compounding*
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Fumarates / chemical synthesis
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Fumarates / chemistry
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Fumarates / isolation & purification
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Pharmaceutical Preparations / chemical synthesis*
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Pharmaceutical Preparations / chemistry
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Pharmaceutical Preparations / isolation & purification
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Technology, Pharmaceutical
Substances
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Acids
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Amides
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Fumarates
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Pharmaceutical Preparations
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aliskiren