Selective imaging of the angiogenic relevant integrins α5β1 and αvβ3

Abstract

Pattern seekers: For the two angiogenic relevant integrins α5β1 and αvβ3, functionalized derivatives of the selective antagonists 1 and 2 could target and discriminate between tumor cells in vivo based on their different integrin patterns and also delay tumor growth in vivo. In addition, the first α5β1-selective integrin antagonist that enables specific molecular imaging by positron emission tomography was developed.

Keywords: RGD sequence; angiogenesis; integrins; peptidomimetics; positron emission tomography.