Abstract
Inspired by the multifunctionality of vitamin D-binding protein and the multiple transient-binding behavior of some intrinsically disordered proteins (IDPs), a polymeric platform is designed, prepared, and characterized for combined delivery of dermal protective and anticancer bioactive cargos on the basis of artificial single-chain nano-objects mimicking IDPs. For the first time ever, simultaneous delivery of folic acid or vitamin B9 , and hinokitiol, a relevant natural bioactive compound that exhibits anticancer activity against human malignant melanoma cells, from these multidirectionally self-assembled unimolecular nanocarriers is illustrated.
Keywords:
drug delivery; nanocarriers; nanomedicine; nanoparticles; self-assembly.
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antineoplastic Agents / administration & dosage
-
Cell Line, Tumor
-
Drug Carriers / chemical synthesis
-
Drug Carriers / chemistry*
-
Folic Acid / administration & dosage
-
Folic Acid / pharmacology
-
Humans
-
Intrinsically Disordered Proteins / chemical synthesis
-
Intrinsically Disordered Proteins / chemistry*
-
Melanoma / drug therapy
-
Melanoma / pathology
-
Molecular Dynamics Simulation
-
Molecular Mimicry
-
Monoterpenes / administration & dosage
-
Nanoparticles / chemistry*
-
Protective Agents / administration & dosage
-
Protective Agents / pharmacology
-
Skin / drug effects
-
Tropolone / administration & dosage
-
Tropolone / analogs & derivatives
Substances
-
Antineoplastic Agents
-
Drug Carriers
-
Intrinsically Disordered Proteins
-
Monoterpenes
-
Protective Agents
-
Tropolone
-
Folic Acid
-
beta-thujaplicin