Design and preparation of single-chain nanocarriers mimicking disordered proteins for combined delivery of dermal bioactive cargos

Macromol Rapid Commun. 2013 Nov;34(21):1681-6. doi: 10.1002/marc.201300562. Epub 2013 Sep 23.

Abstract

Inspired by the multifunctionality of vitamin D-binding protein and the multiple transient-binding behavior of some intrinsically disordered proteins (IDPs), a polymeric platform is designed, prepared, and characterized for combined delivery of dermal protective and anticancer bioactive cargos on the basis of artificial single-chain nano-objects mimicking IDPs. For the first time ever, simultaneous delivery of folic acid or vitamin B9 , and hinokitiol, a relevant natural bioactive compound that exhibits anticancer activity against human malignant melanoma cells, from these multidirectionally self-assembled unimolecular nanocarriers is illustrated.

Keywords: drug delivery; nanocarriers; nanomedicine; nanoparticles; self-assembly.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / administration & dosage
  • Cell Line, Tumor
  • Drug Carriers / chemical synthesis
  • Drug Carriers / chemistry*
  • Folic Acid / administration & dosage
  • Folic Acid / pharmacology
  • Humans
  • Intrinsically Disordered Proteins / chemical synthesis
  • Intrinsically Disordered Proteins / chemistry*
  • Melanoma / drug therapy
  • Melanoma / pathology
  • Molecular Dynamics Simulation
  • Molecular Mimicry
  • Monoterpenes / administration & dosage
  • Nanoparticles / chemistry*
  • Protective Agents / administration & dosage
  • Protective Agents / pharmacology
  • Skin / drug effects
  • Tropolone / administration & dosage
  • Tropolone / analogs & derivatives

Substances

  • Antineoplastic Agents
  • Drug Carriers
  • Intrinsically Disordered Proteins
  • Monoterpenes
  • Protective Agents
  • Tropolone
  • Folic Acid
  • beta-thujaplicin