1H and 13C NMR investigation of 20-hydroxyecdysone dioxolane derivatives, a novel group of MDR modulator agents

Magn Reson Chem. 2013 Dec;51(12):830-6. doi: 10.1002/mrc.4015. Epub 2013 Oct 2.

Abstract

The synthesis, structure elucidation and the complete (1)H and (13)C signal assignment of a series of dioxolane derivatives of 20-hydroxyecdysone, synthesized as novel modulators of multidrug resistance, are presented. The structures and NMR signal assignment were established by comprehensive one-dimensional and two-dimensional NMR spectroscopy supported by mass spectrometry.

Keywords: 13C NMR; 1H NMR; 20-hydroxyecdysone dioxolanes; P-glycoprotein; antitumor agents; stereochemistry.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carbon Isotopes
  • Commelinaceae / chemistry*
  • Dioxolanes / chemical synthesis
  • Dioxolanes / chemistry*
  • Drug Resistance, Multiple
  • Ecdysterone / analogs & derivatives*
  • Ecdysterone / chemical synthesis
  • Ecdysterone / chemistry
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Models, Molecular
  • Molecular Conformation
  • Plant Roots / chemistry*
  • Protons

Substances

  • 20-hydroxyecdysone dioxolane
  • Carbon Isotopes
  • Dioxolanes
  • Protons
  • Ecdysterone