Abstract
We report a case of Alternaria alternata cutaneous and pulmonary infection in a 62-year-old man after heart transplantation treated by azole antifungals. Alternaria spp. belong to a group of opportunistic dematiaceous fungi with worldwide distribution. The cutaneous form of the infection in human is very rare and occurs predominantly among immunosuppressed patients. Therefore, diagnosis is often delayed or not reached at all. Appropriate treatment is not standardized and remains a matter of discussion. According to current studies, the best results are obtained with systemic azole antifungal therapy combined with surgical intervention.
Keywords:
Alternaria alternata; azole antifungals; heart transplantation.
© 2013 Wiley Periodicals, Inc.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Alternaria / drug effects*
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Alternaria / immunology
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Alternaria / pathogenicity
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Alternariosis / diagnosis
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Alternariosis / drug therapy*
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Alternariosis / immunology
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Alternariosis / microbiology
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Antifungal Agents / administration & dosage*
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Dermatomycoses / diagnosis
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Dermatomycoses / drug therapy*
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Dermatomycoses / immunology
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Dermatomycoses / microbiology
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Heart Transplantation / adverse effects*
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Humans
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Immunocompromised Host
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Immunosuppressive Agents / adverse effects
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Lung Diseases, Fungal / diagnosis
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Lung Diseases, Fungal / drug therapy*
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Lung Diseases, Fungal / immunology
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Lung Diseases, Fungal / microbiology
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Male
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Middle Aged
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Opportunistic Infections / diagnosis
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Opportunistic Infections / drug therapy*
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Opportunistic Infections / immunology
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Opportunistic Infections / microbiology
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Treatment Outcome
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Triazoles / administration & dosage*
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Voriconazole / administration & dosage*
Substances
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Antifungal Agents
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Immunosuppressive Agents
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Triazoles
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posaconazole
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Voriconazole