Abstract
Two new phenolics, a 3-substituted coumarin, 7,8-dihydroxy-3-carboxymethylcoumarin-5-carboxylic acid, and a hydrolyzable tannin, namely punicatannin C, together with 10 known phenolics, were isolated from the flowers of pomegranate (Punica granatum). Their structures were determined on the basis of extensive spectroscopic analyses including HRESIMS, 1D and 2D NMR data. All the isolates were evaluated for in vitro α-glucosidase inhibitory activities.
Georg Thieme Verlag KG Stuttgart · New York.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Coumarins / chemistry
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Coumarins / isolation & purification
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Coumarins / pharmacology*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification*
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Enzyme Inhibitors / pharmacology
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Flowers / chemistry*
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Hydrolyzable Tannins / chemistry
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Hydrolyzable Tannins / isolation & purification
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Hydrolyzable Tannins / pharmacology*
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Lythraceae / chemistry*
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Molecular Structure
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Phenols / chemistry
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Phenols / isolation & purification
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Phenols / pharmacology
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Plant Extracts / chemistry
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Plant Extracts / pharmacology*
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Rats
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alpha-Glucosidases / chemistry
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alpha-Glucosidases / isolation & purification
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alpha-Glucosidases / pharmacology*
Substances
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7,8-dihydroxy-3-carboxymethylcoumarin-5-carboxylic acid
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Coumarins
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Enzyme Inhibitors
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Hydrolyzable Tannins
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Phenols
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Plant Extracts
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punicatannin C
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alpha-Glucosidases