Abstract
EPS8 was first identified as a tyrosine kinase substrate, that plays a role in EGFR-mediated mitogenic signaling. Recent research has shown that EPS8 is overexpressed in most types of cancer, for example breast cancer, colon cancer, cervical cancer and even hematologic malignancies. EPS8 is involved in many signaling pathways related to tumorigenesis, proliferation, migration and metastasis, and is a biomarker for poor prognosis of cancer patients. This review aims to provide a comprehensive picture of the role of EPS8 in cellular processes and its significance to tumorigenesis. Furthermore, this review focuses on the potential role of EPS8 as a therapeutic cancer target.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adaptor Proteins, Signal Transducing / antagonists & inhibitors
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Adaptor Proteins, Signal Transducing / chemistry
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Adaptor Proteins, Signal Transducing / genetics
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Adaptor Proteins, Signal Transducing / metabolism*
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Antineoplastic Agents / pharmacology
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Antineoplastic Agents / therapeutic use
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Cell Transformation, Neoplastic / genetics
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Cell Transformation, Neoplastic / metabolism
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Humans
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Molecular Targeted Therapy
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Neoplasm Invasiveness
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Neoplasm Metastasis
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Neoplasms / drug therapy
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Neoplasms / metabolism*
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Neoplasms / pathology
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Oncogene Proteins / antagonists & inhibitors
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Oncogene Proteins / chemistry
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Oncogene Proteins / genetics
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Oncogene Proteins / metabolism*
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Signal Transduction / drug effects
Substances
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Adaptor Proteins, Signal Transducing
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Antineoplastic Agents
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EPS8 protein, human
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Oncogene Proteins