Functionalization of polycarbonate surfaces by grafting PEG and zwitterionic polymers with a multicomb structure

Macromol Biosci. 2013 Dec;13(12):1681-8. doi: 10.1002/mabi.201300264. Epub 2013 Sep 17.

Abstract

The hemocompatibility of polycarbonateurethane (PCU) surfaces is improved by decoration with poly(poly(ethylene glycol) methacrylate) (poly(PEGMA)) and zwitterionic poly(3-((2-(methacryloyloxy)ethyl)dimethylammonio)propane-1-sulfonate) (poly(DMAPS)) blocks providing a novel multicomb structure obtained by application of surface-initiated atom transfer radical polymerization (s-ATRP) conditions. The PCU-poly(PEGMA-g-DMAPS) surface shows high hydrophilicity with a low contact angle of 20.6 ± 1.8°, while PCU-poly(PEGMA-b-DMAPS) surface exhibitsed a contact angle of 30.5 ± 2.6°. Furthermore, PCU-poly(PEGMA-g-DMAPS) surface shows very low platelet adsorption indicating that multicomb structure modified PCUs are preferred candidate materials for blood-contacting materials.

Keywords: ATRP; biomaterials; graft copolymers; hemocompatibility; polyurethanes; zwitterionic polymer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biocompatible Materials / chemical synthesis*
  • Biocompatible Materials / pharmacology
  • Blood Platelets / cytology
  • Blood Platelets / drug effects
  • Cells, Cultured
  • Hydrophobic and Hydrophilic Interactions
  • Methacrylates / chemistry*
  • Platelet Adhesiveness / drug effects
  • Polycarboxylate Cement / chemistry*
  • Polyethylene Glycols / chemistry*
  • Polymethacrylic Acids
  • Polyurethanes / chemistry*
  • Quaternary Ammonium Compounds / chemistry*
  • Rabbits
  • Surface Properties

Substances

  • 3-dimethyl(methacryloyloxyethyl)ammonium propane sulfonate
  • Biocompatible Materials
  • Methacrylates
  • Polycarboxylate Cement
  • Polymethacrylic Acids
  • Polyurethanes
  • Quaternary Ammonium Compounds
  • poly(poly(ethylene glycol)methacrylate)
  • polycarbonate
  • Polyethylene Glycols