It takes two to tango: Dual inhibition of PI3K and MAPK in rhabdomyosarcoma

Clin Cancer Res. 2013 Nov 1;19(21):5811-3. doi: 10.1158/1078-0432.CCR-13-2177. Epub 2013 Oct 4.

Abstract

The PI3K/AKT/mTOR and RAS/RAF/MAPK pathways play essential roles in rhabdomyosarcoma. Singular targeting of each pathway is ineffective due to extensive cross-talk and compensatory feedback between these two pathways. Dual blockade with inhibitors of PI3K and MAPK in combination synergistically inhibits growth of rhabdomyosarcoma both in vitro and in vivo.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Female
  • Humans
  • Mitogen-Activated Protein Kinases / metabolism*
  • Phosphatidylinositol 3-Kinases / metabolism*
  • Proto-Oncogene Proteins c-akt / metabolism*
  • Proto-Oncogene Proteins p21(ras) / metabolism*
  • Rhabdomyosarcoma / metabolism*
  • Rhabdomyosarcoma / pathology*
  • Signal Transduction*
  • TOR Serine-Threonine Kinases / metabolism*

Substances

  • Proto-Oncogene Proteins c-akt
  • TOR Serine-Threonine Kinases
  • Mitogen-Activated Protein Kinases
  • Proto-Oncogene Proteins p21(ras)