Glycaemic instability correlates with a hyperglucagonaemic response in patients with type 1 diabetes without residual beta-cell function

Megumi Bessho; Yuko Murase-Mishiba; Chiharu Tsutsumi; Fumitaka Haseda; Akihisa Imagawa; Jungo Terasaki; Toshiaki Hanafusa

doi:10.1016/j.diabres.2013.09.003

Glycaemic instability correlates with a hyperglucagonaemic response in patients with type 1 diabetes without residual beta-cell function

Diabetes Res Clin Pract. 2013 Nov;102(2):e38-40. doi: 10.1016/j.diabres.2013.09.003. Epub 2013 Sep 16.

Authors

Megumi Bessho¹, Yuko Murase-Mishiba, Chiharu Tsutsumi, Fumitaka Haseda, Akihisa Imagawa, Jungo Terasaki, Toshiaki Hanafusa

Affiliation

¹ Department of Internal Medicine (I), Osaka Medical College, Osaka, Japan.

PMID: 24095157
DOI: 10.1016/j.diabres.2013.09.003

Abstract

We investigated the association between arginine-stimulated glucagon secretion (AUCIRG) and several parameters of glycaemic variability in 12 patients with type 1 diabetes without residual beta-cell function. AUCIRG positively correlated with the SD and mean amplitude of glycaemic excursions, thus glucagon might contribute to glycaemic instability, independent of endogenous insulin.

Keywords: Glucagon; Glycaemic instability; Type 1 diabetes.

MeSH terms

Adult
Area Under Curve
Blood Glucose / physiology*
Diabetes Mellitus, Type 1 / blood*
Diabetes Mellitus, Type 1 / metabolism
Female
Glucagon / blood*
Humans
Hypoglycemic Agents / therapeutic use
Insulin / therapeutic use
Insulin-Secreting Cells / physiology*
Male
Middle Aged

Substances

Blood Glucose
Hypoglycemic Agents
Insulin
Glucagon