The sacred disease: the puzzling genetics of epileptic disorders

Gaia Novarino; Seung Tae Baek; Joseph G Gleeson

doi:10.1016/j.neuron.2013.09.019

The sacred disease: the puzzling genetics of epileptic disorders

Neuron. 2013 Oct 2;80(1):9-11. doi: 10.1016/j.neuron.2013.09.019. Epub 2013 Oct 2.

Authors

Gaia Novarino¹, Seung Tae Baek, Joseph G Gleeson

Affiliation

¹ Howard Hughes Medical Institute, Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA.

Abstract

In the September 12, 2013 issue of Nature, the Epi4K Consortium (Allen et al., 2013) reported sequencing 264 patient trios with epileptic encephalopathies. The Consortium focused on genes exceptionally intolerant to sequence variations and found substantial interconnections with autism and intellectual disability gene networks.

Publication types

Comment

MeSH terms

Female
Humans
Intellectual Disability / genetics*
Male
Mutation / genetics*
Spasms, Infantile / genetics*

Abstract

Publication types

MeSH terms

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