Facile synthesis of peptidyl salicylaldehyde esters and its use in cyclic peptide synthesis

Org Lett. 2013 Oct 18;15(20):5182-5. doi: 10.1021/ol402279h. Epub 2013 Oct 4.

Abstract

An efficient solid phase synthetic protocol for salicylaldehyde ester peptides is reported. With a Ser or Thr at the N-terminus, these salicylaldehyde ester peptides can be easily converted to Ser/Thr containing cyclic peptides.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemical synthesis*
  • Aldehydes / chemistry
  • Esters / chemical synthesis*
  • Esters / chemistry
  • Molecular Structure
  • Peptides / chemical synthesis*
  • Peptides / chemistry
  • Peptides, Cyclic / chemical synthesis*
  • Peptides, Cyclic / chemistry

Substances

  • Aldehydes
  • Esters
  • Peptides
  • Peptides, Cyclic
  • salicylaldehyde