Your gut is right to turn left

Dev Cell. 2013 Sep 30;26(6):553-4. doi: 10.1016/j.devcel.2013.08.018.

Abstract

Transcriptional factor Pitx2 is a key regulator of left-right asymmetry in the developing gut. In this issue of Developmental Cell, Welsh et al. (2013) identify the formin Daam2, an effector of Wnt signaling, as a key cellular target of Pitx2 required for morphogenetic events during asymmetric gut formation.

Publication types

  • Comment

MeSH terms

  • Animals
  • Gastrulation*
  • Homeobox Protein PITX2
  • Homeodomain Proteins / metabolism*
  • Intestines / embryology*
  • Microfilament Proteins / metabolism*
  • Transcription Factors / metabolism*
  • Transcription, Genetic*
  • Wnt Signaling Pathway*
  • rho GTP-Binding Proteins / metabolism*

Substances

  • Daam2 protein, mouse
  • Homeodomain Proteins
  • Microfilament Proteins
  • Transcription Factors
  • rho GTP-Binding Proteins