Abstract
Transcriptional factor Pitx2 is a key regulator of left-right asymmetry in the developing gut. In this issue of Developmental Cell, Welsh et al. (2013) identify the formin Daam2, an effector of Wnt signaling, as a key cellular target of Pitx2 required for morphogenetic events during asymmetric gut formation.
Copyright © 2013 Elsevier Inc. All rights reserved.
MeSH terms
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Animals
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Gastrulation*
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Homeobox Protein PITX2
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Homeodomain Proteins / metabolism*
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Intestines / embryology*
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Microfilament Proteins / metabolism*
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Transcription Factors / metabolism*
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Transcription, Genetic*
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Wnt Signaling Pathway*
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rho GTP-Binding Proteins / metabolism*
Substances
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Daam2 protein, mouse
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Homeodomain Proteins
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Microfilament Proteins
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Transcription Factors
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rho GTP-Binding Proteins