Abstract
Three new polyketides penicitrinol G (1), penicitrinol H (2) and 2,11-dihydroxy-1-methoxycarbonyl-9-carboxylxanthone (3) together with one known cathepsin B inhibitor chrysophanol (4) were isolated from a culture broth of marine-derived fungus Penicillium citrinum SCSGAF 0167. Their structures were determined by spectroscopic methods. Compound 4 exhibited inhibitory activity against cathepsin B with IC50 value of 1.7 μM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anthraquinones / pharmacology
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Cathepsin B / antagonists & inhibitors*
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Citrinin / analogs & derivatives*
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Citrinin / chemistry
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Citrinin / isolation & purification*
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Citrinin / pharmacology
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Inhibitory Concentration 50
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Marine Biology
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Oceans and Seas
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Penicillium / chemistry*
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Polyketides / chemistry
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Polyketides / isolation & purification*
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Polyketides / pharmacology
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Xanthones / chemistry
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Xanthones / isolation & purification*
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Xanthones / pharmacology
Substances
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2,11-dihydroxy-1-methoxycarbonyl-9-carboxylxanthone
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Anthraquinones
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Polyketides
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Xanthones
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penicitrinol G
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penicitrinol H
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Citrinin
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Cathepsin B
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chrysophanic acid