Synthesis and evaluation of cyanine-styryl dyes with enhanced photostability for fluorescent DNA staining

Org Biomol Chem. 2013 Nov 21;11(43):7458-62. doi: 10.1039/c3ob41717d.

Abstract

The photostability of cyanine-styryl dyes of the indole-quinolinium type can be significantly improved by structural variations while the excellent optical properties including the bright fluorescence in the presence of DNA can be maintained or even improved, too.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzothiazoles / chemical synthesis
  • Benzothiazoles / chemistry*
  • Carbocyanines / chemical synthesis
  • Carbocyanines / chemistry*
  • DNA / analysis*
  • DNA / chemistry*
  • Fluorescence*
  • Fluorescent Dyes / chemical synthesis*
  • Fluorescent Dyes / chemistry*
  • Molecular Structure
  • Photochemical Processes
  • Spectrometry, Fluorescence
  • Staining and Labeling / methods*

Substances

  • Benzothiazoles
  • Carbocyanines
  • Fluorescent Dyes
  • benzothiazole styrylcyanine
  • DNA