We analyzed effectiveness and safety of anticoagulant therapy in patients with prostheses of cardiac valves at the background of educational program and without special training. We revealed positive effect of educational program during participation in which in 80 cases (67.8%) patients determined international normalized ratio every month and in 50 of them (62,5%) level of hypocoagulation corresponded to target range (p=0.001). At the background of educational program rate of thrombotic complications was 2.73% per patient year, at the background of no educational program - 4.90% per patient year (p=0.040) while rates of hemorrhagic complications were 2.73 and 7.20% per patient year, respectively (p=0.002).