Four new C18-diterpenoid alkaloids with analgesic activity from Aconitum weixiense

Fitoterapia. 2013 Dec:91:280-283. doi: 10.1016/j.fitote.2013.09.013. Epub 2013 Sep 29.

Abstract

Four new C18-diterpenoid alkaloids, weisaconitines A-D (1-4), were isolated from Aconitum weixiense. Based on extensive UV, IR, MS, 1D and 2D NMR analyses, their structures were elucidated as 8-O-ethyldolaconine (1), 4-demethylgenicunine B (2), 14-oxoaconosine (3), and 8-O-ethylaconosine (4). The analgesic activity of compound 4 was studied with CH3COOH-induced writhing model in mice. Compound 4 showed writhing inhibitions of 24% (50 mg/kg), 26% (100 mg/kg) and 34% (200 mg/kg), respectively, as compared to the reference drug aspirin (63%) at a dose of 200 mg/kg.

Keywords: Aconitum weixiense; Analgesic activity; Diterpenoid alkaloids; Ranunculaceae; Weisaconitines A–D.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetic Acid
  • Aconitine / analogs & derivatives*
  • Aconitine / chemistry
  • Aconitine / isolation & purification
  • Aconitine / pharmacology
  • Aconitine / therapeutic use
  • Aconitum / chemistry*
  • Analgesics / chemistry
  • Analgesics / isolation & purification
  • Analgesics / pharmacology
  • Analgesics / therapeutic use*
  • Animals
  • Drugs, Chinese Herbal / isolation & purification
  • Drugs, Chinese Herbal / pharmacology
  • Drugs, Chinese Herbal / therapeutic use
  • Mice
  • Mice, Inbred Strains
  • Molecular Structure
  • Pain / chemically induced
  • Pain / drug therapy*
  • Phytotherapy

Substances

  • 8-O-ethylaconosine
  • Analgesics
  • Drugs, Chinese Herbal
  • Acetic Acid
  • Aconitine