Abstract
Four new C18-diterpenoid alkaloids, weisaconitines A-D (1-4), were isolated from Aconitum weixiense. Based on extensive UV, IR, MS, 1D and 2D NMR analyses, their structures were elucidated as 8-O-ethyldolaconine (1), 4-demethylgenicunine B (2), 14-oxoaconosine (3), and 8-O-ethylaconosine (4). The analgesic activity of compound 4 was studied with CH3COOH-induced writhing model in mice. Compound 4 showed writhing inhibitions of 24% (50 mg/kg), 26% (100 mg/kg) and 34% (200 mg/kg), respectively, as compared to the reference drug aspirin (63%) at a dose of 200 mg/kg.
Keywords:
Aconitum weixiense; Analgesic activity; Diterpenoid alkaloids; Ranunculaceae; Weisaconitines A–D.
© 2013.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetic Acid
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Aconitine / analogs & derivatives*
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Aconitine / chemistry
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Aconitine / isolation & purification
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Aconitine / pharmacology
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Aconitine / therapeutic use
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Aconitum / chemistry*
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Analgesics / chemistry
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Analgesics / isolation & purification
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Analgesics / pharmacology
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Analgesics / therapeutic use*
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Animals
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Drugs, Chinese Herbal / isolation & purification
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Drugs, Chinese Herbal / pharmacology
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Drugs, Chinese Herbal / therapeutic use
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Mice
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Mice, Inbred Strains
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Molecular Structure
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Pain / chemically induced
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Pain / drug therapy*
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Phytotherapy
Substances
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8-O-ethylaconosine
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Analgesics
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Drugs, Chinese Herbal
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Acetic Acid
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Aconitine