Inhibitory effect of oxygenated cholestan-3β-ol derivatives on the growth of Mycobacterium tuberculosis

Bioorg Med Chem Lett. 2013 Nov 15;23(22):6111-3. doi: 10.1016/j.bmcl.2013.09.013. Epub 2013 Sep 14.

Abstract

A variety of cholestan-3β-ol derivatives, which are oxygenated at different positions of the steroid ring system, were prepared and tested for their inhibition of the Mycobacterium tuberculosis H37Rv strain. Several compounds showed significant antitubercular activities with MIC90 values in the range 4-8 μM and low or non-detectable toxicity against mammalian cells.

Keywords: Anti-TB activity; Cholestanols; Inhibition; Steroids; Tuberculosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antitubercular Agents / pharmacology*
  • Cholestanols / chemical synthesis
  • Cholestanols / chemistry
  • Cholestanols / pharmacology*
  • Humans
  • Microbial Sensitivity Tests
  • Mycobacterium tuberculosis / drug effects*
  • Mycobacterium tuberculosis / growth & development
  • Oxidation-Reduction
  • Stereoisomerism
  • Structure-Activity Relationship

Substances

  • Antitubercular Agents
  • Cholestanols