Alveolar capillary dysplasia (ACD) with misalignment of pulmonary veins (MPV) is a lethal neonatal lung disease. Death from ACD/MPV is caused by hypoxia, but the role of the MPV is unknown. Using 3-dimensional reconstruction of ACD/MPV lung tissue, we report that the veins in MPV are intrapulmonary shunt vessels, and speculate that MPV contributes to the poor prognosis.
Keywords: 3-dimensional; 3D; ACD; Alveolar capillary dysplasia; IPSV; Intrapulmonary shunt vessels; MPV; Misalignment of pulmonary veins; PPHN; Persistent pulmonary hypertension of the newborn.
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