Abstract
As part of a project to generate a library of nucleosides as potential antiviral agents, a small subset of novel acyclic phosphonic acid nucleosides was prepared. Practical synthetic routes are described for three targets, which were then tested against HIV, hepatitis C virus (HCV), and Dengue virus.
MeSH terms
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Acids, Acyclic / chemical synthesis*
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Acids, Acyclic / chemistry
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / chemistry
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Dengue / drug therapy
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Dengue Virus / drug effects
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HIV / drug effects
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HIV Infections / drug therapy
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Hepacivirus / drug effects
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Humans
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Molecular Structure
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Nucleosides / chemical synthesis*
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Nucleosides / chemistry
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Phosphorous Acids / chemical synthesis*
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Phosphorous Acids / chemistry
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Phosphorylation
Substances
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Acids, Acyclic
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Antiviral Agents
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Nucleosides
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Phosphorous Acids
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phosphonic acid