Microbial biotransformation of 16α,17-epoxy-ent-kaurane-19-oic acid by Beauveria sulfurescens ATCC 7159-F

Nat Prod Commun. 2013 Aug;8(8):1041-4.

Abstract

Biotransformation of 16alpha,17-epoxy-ent-kaurane-19-oic acid (1) by Beauveria sulfurescens ATCC 7159-F led to the production of a new ent-kaurane diterpenoid, 7beta,17-dihydroxy-ent-kaur-15-en-19-oic acid (7), and four other ent-kauranes (8 - 11), all of which were identified as their methyl esters. Compounds 9 and 10 were found to be new stereoisomers. Structures of these were established by the extensive usage of their spectroscopic characteristics.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Beauveria / metabolism*
  • Biotransformation
  • Diterpenes, Kaurane / metabolism*
  • Stereoisomerism

Substances

  • 16alpha,17-epoxy-ent-kaurane-19-oic acid
  • Diterpenes, Kaurane