Direct access to highly substituted 1-naphthols through palladium-catalyzed oxidative annulation of benzoylacetates and internal alkynes

Chemistry. 2013 Sep 27;19(40):13322-7. doi: 10.1002/chem.201302740.

Abstract

One for the pot: 1-Naphthols, well-known structural design elements in medicinal chemistry, were readily prepared by means of a one-pot palladium-catalyzed oxidative annulation of readily available benzoylacetates to internal alkynes.

Keywords: CH activation; alkynes; annulation; naphthols; palladium.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes / chemistry*
  • Benzoates / chemistry*
  • Catalysis
  • Molecular Structure
  • Naphthols / chemical synthesis*
  • Naphthols / chemistry*
  • Oxidation-Reduction
  • Palladium / chemistry

Substances

  • Alkynes
  • Benzoates
  • Naphthols
  • 1-naphthol
  • Palladium