Synthesis and antibacterial evaluation of some novel imidazole and benzimidazole sulfonamides

Nassir N Al-Mohammed; Yatimah Alias; Zanariah Abdullah; Raied M Shakir; Ekhlass M Taha; Aidil Abdul Hamid

doi:10.3390/molecules181011978

Synthesis and antibacterial evaluation of some novel imidazole and benzimidazole sulfonamides

Molecules. 2013 Sep 26;18(10):11978-95. doi: 10.3390/molecules181011978.

Authors

Nassir N Al-Mohammed¹, Yatimah Alias, Zanariah Abdullah, Raied M Shakir, Ekhlass M Taha, Aidil Abdul Hamid

Affiliation

¹ Chemistry Department, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia. nassir@siswa.um.edu.my.

Abstract

Several new substituted sulfonamide compounds were synthesized and their structures were confirmed by ¹H-NMR, ¹³C-NMR, FT-IR, and mass spectroscopy. The antibacterial activities of the synthesized compounds were screened against standard strains of six Gram positive and four Gram negative bacteria using the microbroth dilution assay. Most of the compounds studied showed promising activities against both types of bacteria.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Benzimidazoles / chemical synthesis*
Benzimidazoles / pharmacology
Gram-Negative Bacteria / drug effects
Gram-Positive Bacteria / drug effects
Imidazoles / chemical synthesis*
Imidazoles / pharmacology
Microbial Sensitivity Tests
Spectroscopy, Fourier Transform Infrared
Sulfonamides / chemical synthesis*
Sulfonamides / pharmacology

Substances

Benzimidazoles
Imidazoles
Sulfonamides