Abstract
The irreversible inhibition of acetylcholinesterase (AChE) by organophosphorous chemical warfare agents necessitates that antidotes be administered for effective treatment. Currently no antidote is known that resurrects the phosphyl-AChE complex once aging has occurred. This report characterizes the affinities of over 30 new AChE inhibitors which could act as resurrecting agents for the aged AChE-OP adduct.
Keywords:
2-Methoxypyridinium compounds; Acetylcholinesterase; Reversible inhibition.
Copyright © 2013. Published by Elsevier Ltd.
Publication types
-
Research Support, N.I.H., Extramural
MeSH terms
-
Acetylcholinesterase / chemistry
-
Acetylcholinesterase / metabolism*
-
Antidotes / chemistry
-
Antidotes / pharmacology
-
Chemical Warfare Agents / pharmacology
-
Cholinesterase Inhibitors / chemistry*
-
Cholinesterase Inhibitors / pharmacology*
-
Humans
-
Organophosphorus Compounds / pharmacology
-
Pyridinium Compounds / chemistry*
-
Pyridinium Compounds / pharmacology*
-
Structure-Activity Relationship
Substances
-
Antidotes
-
Chemical Warfare Agents
-
Cholinesterase Inhibitors
-
Organophosphorus Compounds
-
Pyridinium Compounds
-
Acetylcholinesterase