Dendrimer-folate-copper conjugates as bioprobes for synchrotron X-ray fluorescence imaging

Chem Commun (Camb). 2013 Nov 14;49(88):10388-90. doi: 10.1039/c3cc46057f.

Abstract

We present a bioprobe for synchrotron X-ray fluorescence imaging based on dendrimer-folate-copper conjugates. The metal nanoclusters within a dendrimer exhibit excellent FR-targeting properties in KB cells. It could be used as a new multifunction bioprobe for synchrotron X-ray fluorescence mapping.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Copper / chemistry*
  • Dendrimers / chemistry*
  • Folic Acid / chemistry*
  • Humans
  • KB Cells
  • Molecular Probes / chemistry*
  • Molecular Probes / metabolism
  • Optical Imaging / instrumentation
  • Optical Imaging / methods*
  • Synchrotrons*
  • X-Rays

Substances

  • Dendrimers
  • Molecular Probes
  • Copper
  • Folic Acid