A genetic polymorphism in TOX3 is associated with survival of gastric cancer in a Chinese population

Xiaojing Zhang; Haixia Zhu; Xiaomin Wu; Meilin Wang; Dongying Gu; Weida Gong; Zhi Xu; Yongfei Tan; Yongling Gong; Jianwei Zhou; Cuiju Tang; Na Tong; Jinfei Chen; Zhengdong Zhang

doi:10.1371/journal.pone.0072186

A genetic polymorphism in TOX3 is associated with survival of gastric cancer in a Chinese population

PLoS One. 2013 Sep 17;8(9):e72186. doi: 10.1371/journal.pone.0072186. eCollection 2013.

Authors

Xiaojing Zhang¹, Haixia Zhu, Xiaomin Wu, Meilin Wang, Dongying Gu, Weida Gong, Zhi Xu, Yongfei Tan, Yongling Gong, Jianwei Zhou, Cuiju Tang, Na Tong, Jinfei Chen, Zhengdong Zhang

Affiliation

¹ Department of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, P. R. China ; Department of Gynecologic Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, P.R. China.

Abstract

Purpose: Recently, genetic polymorphism (rs3803662C>T) in TOX3 was reported to induce the risk of breast cancer. In this study, we hypothesized that rs3803662 could influence gastric cancer survival outcomes.

Methods: With multiplex SNaPshot method, we genotyped TOX3 rs3803662 in 880 gastric patients with surgical resection. The association between genotype and survival outcomes was performed by the Kaplan-Meier method, Cox regression analysis models and the log-rank test.

Results: There was no association in the analyses of rs3803662 and survival of gastric cancer. However, the stratified analysis by histology showed that rs3803662 CT/TT genotype was associated with a significantly better survival for diffuse-type gastric cancer (log-rank p = 0.030, hazard ratio [HR] = 0.67, 95% confidence interval [CI] = 0.46-0.96), than the CC genotype. In addition, this favorable effect was especially obvious among gastric cancer patients with tumor size >5 cm, T3 and T4 depth of invasion, lymph node metastasis, no drinking, no distant metastasis, no chemotherapy and gastric cardia cancer.

Conclusions: TOX3 rs3803662 might play an important role in the prognostic outcome and treatment of gastric cancer, especially perhaps further help in explaining the reduced risk of death associated with diffuse-type gastric cancer.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Apoptosis Regulatory Proteins
Asian People / genetics
Female
Genotype
High Mobility Group Proteins
Humans
Male
Middle Aged
Polymorphism, Genetic / genetics
Polymorphism, Single Nucleotide / genetics
Receptors, Progesterone / genetics*
Stomach Neoplasms / genetics*
Trans-Activators

Substances

Apoptosis Regulatory Proteins
High Mobility Group Proteins
Receptors, Progesterone
TOX3 protein, human
Trans-Activators

Grants and funding

The work was supported by grants from National Natural Science Foundation of China to Dr. J Chen (Grant No. 81071641), Dr. Z Xu (Grant No. 81000880); a grant from National Basic Science Research Program to Dr. J Chen (2013CB911300); a grant from Jiangsu Provincial 12th Five-Year Program on Developing Health by Technology and Education Project to Dr. J Chen, Dr. H. Zhu (Grant No. 81001274), Dr. Z Zhang (30972444, 81230068 and BK2010080), Dr. M. Wang (81102089 and BK2011773), the Qin Lan Project of Jiangsu Provincial Department of Education, and by the Priority Academic Program Development of Jiangsu Higher Education Institutions (Public Health and Preventive Medicine). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.