Abstract
Phytochemical investigation of Aglaia duppereana flowers led to the isolation of a new rocaglamide derivative and twelve known congeners. The structure of the new compound was unambiguously elucidated by spectroscopic techniques (1D- and 2D-NMR, HRESIMS). The isolated compounds exhibited a potent cytotoxic activity against mouse lymphoma (L5178Y) cells with EC50 values ranging from 5.1 to 54.8 nM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aglaia / chemistry*
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Animals
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology*
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Benzofurans / chemistry
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Benzofurans / pharmacology*
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Cell Line, Tumor
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Drug Screening Assays, Antitumor
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Magnetic Resonance Spectroscopy
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Mice
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Molecular Structure
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Spectrometry, Mass, Electrospray Ionization
Substances
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Antineoplastic Agents, Phytogenic
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Benzofurans
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rocaglamide