Cytotoxic rocaglamide derivatives from Aglaia duppereana

Z Naturforsch C J Biosci. 2013 Jul-Aug;68(7-8):269-74.

Abstract

Phytochemical investigation of Aglaia duppereana flowers led to the isolation of a new rocaglamide derivative and twelve known congeners. The structure of the new compound was unambiguously elucidated by spectroscopic techniques (1D- and 2D-NMR, HRESIMS). The isolated compounds exhibited a potent cytotoxic activity against mouse lymphoma (L5178Y) cells with EC50 values ranging from 5.1 to 54.8 nM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aglaia / chemistry*
  • Animals
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Benzofurans / chemistry
  • Benzofurans / pharmacology*
  • Cell Line, Tumor
  • Drug Screening Assays, Antitumor
  • Magnetic Resonance Spectroscopy
  • Mice
  • Molecular Structure
  • Spectrometry, Mass, Electrospray Ionization

Substances

  • Antineoplastic Agents, Phytogenic
  • Benzofurans
  • rocaglamide