Incidence of bovine leukocyte adhesion deficiency, complex vertebral malformation, and deficiency of uridine-5-monophosphate synthase carriers in Brazilian Girolando cattle

Genet Mol Res. 2013 Aug 29;12(3):3186-92. doi: 10.4238/2013.August.29.2.

Abstract

Among the various hereditary diseases that have been widely studied in dairy cattle, bovine leukocyte adhesion deficiency (BLAD), deficiency of uridine-5-monophosphate synthase (DUMPS), and complex vertebral malformation (CVM) are noteworthy because of their high impact on overall herd productivity as a consequence of increased calf mortality. The aim of this study was to verify the frequency of carriers of BLAD, CVM, and DUMPS mutant alleles in cows and bulls from the National Girolando Progeny Test carried out in Brazil by using polymerase chain reaction (PCR)-restriction fragment length polymorphism and allele-specific PCR assays. A total of 777 animals were genotyped for BLAD, 783 for CVM, and 122 for DUMPS. The frequencies of carriers for BLAD and CVM were 0.77 and 1.53%, respectively, whereas no carriers of DUMPS were observed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brazil
  • Cattle
  • Cattle Diseases / genetics*
  • Cattle Diseases / pathology
  • Female
  • Gene Frequency / genetics*
  • Genotype
  • Leukocyte-Adhesion Deficiency Syndrome / genetics*
  • Leukocyte-Adhesion Deficiency Syndrome / veterinary
  • Male
  • Multienzyme Complexes / deficiency
  • Multienzyme Complexes / genetics*
  • Orotate Phosphoribosyltransferase / deficiency
  • Orotate Phosphoribosyltransferase / genetics*
  • Orotidine-5'-Phosphate Decarboxylase / deficiency
  • Orotidine-5'-Phosphate Decarboxylase / genetics*
  • Polymorphism, Restriction Fragment Length
  • Spine / pathology

Substances

  • Multienzyme Complexes
  • uridine 5'-monophosphate synthase
  • Orotate Phosphoribosyltransferase
  • Orotidine-5'-Phosphate Decarboxylase