Enhancement of the photocytotoxic efficiency of sub-12 nm therapeutic polymeric micelles with increased co-localisation in mitochondria

Chem Commun (Camb). 2013 Dec 21;49(98):11476-8. doi: 10.1039/c3cc46166a.

Abstract

We engineered phototherapeutic sub-12 nm-sized polymeric micelles to treat malignant brain tumours (MBTs). The engineered nanoparticles in MBT cells enhanced the photocytotoxic efficiency more than 2.5-fold compared with parental and PEGylated photosensitisers (PSs). Increased subcellular co-localisation of PSs in mitochondria was observed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anthracenes
  • Brain Neoplasms / drug therapy
  • Brain Neoplasms / metabolism*
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Cell Survival / radiation effects
  • Humans
  • Light
  • Micelles
  • Mitochondria / metabolism*
  • Nanoparticles / administration & dosage
  • Perylene / administration & dosage
  • Perylene / analogs & derivatives*
  • Phosphatidylethanolamines / chemistry
  • Photochemotherapy*
  • Photosensitizing Agents / administration & dosage*
  • Polyethylene Glycols / chemistry

Substances

  • Anthracenes
  • Micelles
  • Phosphatidylethanolamines
  • Photosensitizing Agents
  • 1,2-distearoylphosphatidylethanolamine
  • Polyethylene Glycols
  • Perylene
  • hypericin
  • monomethoxypolyethylene glycol