Abstract
Two new indolo[3,2-a]carbazoles (1, 2) were isolated from a deep-water collection of a sponge of the genus Asteropus. The structures of 1 and 2 were determined through the analysis of spectroscopic data including mass spectrometry and 2D-NMR. Compound 1 showed minimum inhibitory concentrations of 25 μg/mL against the fungal pathogen Candida albicans and 50 μg/mL against methicillin-resistant Staphylococcus aureus (MRSA). Compounds 1 and 2 showed no cytotoxicity against the PANC1 human pancreatic carcinoma and NCI/ADR-RES ovarian adenocarcinoma cell lines at our standard test concentration of 5 μg/mL.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology
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Bahamas
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Candida albicans / drug effects
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Carbazoles / chemistry
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Carbazoles / isolation & purification*
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Carbazoles / pharmacology
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Drug Screening Assays, Antitumor
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Heterocyclic Compounds, 4 or More Rings / chemistry
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Heterocyclic Compounds, 4 or More Rings / isolation & purification*
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Heterocyclic Compounds, 4 or More Rings / pharmacology
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Humans
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Indoles / chemistry
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Indoles / isolation & purification*
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Indoles / pharmacology
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Methicillin Resistance / drug effects
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Methicillin-Resistant Staphylococcus aureus / drug effects
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Microbial Sensitivity Tests
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Porifera / chemistry*
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Staphylococcus aureus / drug effects
Substances
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Anti-Bacterial Agents
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Carbazoles
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Heterocyclic Compounds, 4 or More Rings
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Indoles