Single-base DNA discrimination via transverse ionic transport

Nanotechnology. 2013 Oct 18;24(41):415101. doi: 10.1088/0957-4484/24/41/415101. Epub 2013 Sep 24.

Abstract

We suggest the discrimination of single DNA bases via transverse ionic transport, namely by detecting the ionic current that flows in a channel while a single-stranded DNA is driven through an intersecting nanochannel. Our all-atom molecular dynamics simulations indeed show that the ionic currents of the four bases are statistically distinct, thus offering another possible approach to sequencing DNA.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Base Sequence
  • DNA, Single-Stranded / chemistry*
  • DNA, Single-Stranded / metabolism*
  • Ion Transport
  • Ions / metabolism*
  • Molecular Dynamics Simulation
  • Nucleic Acid Conformation

Substances

  • DNA, Single-Stranded
  • Ions