Seroprevalence of human herpesvirus-8 in HIV-1 infected and uninfected individuals in Cameroon

Christelle Mbondji-Wonje; Viswanath Ragupathy; Sherwin Lee; Owen Wood; Bih Awazi; Indira K Hewlett

doi:10.3390/v5092253

Seroprevalence of human herpesvirus-8 in HIV-1 infected and uninfected individuals in Cameroon

Viruses. 2013 Sep 19;5(9):2253-9. doi: 10.3390/v5092253.

Authors

Christelle Mbondji-Wonje¹, Viswanath Ragupathy, Sherwin Lee, Owen Wood, Bih Awazi, Indira K Hewlett

Affiliation

¹ Division of Emerging and Transmission Transmitted Diseases, Office of Blood Review and Research, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA. Christelle.Mbondji@fda.hhs.gov

Abstract

We evaluated the prevalence of HHV-8 antibodies in 516 plasma samples collected from HIV positive and negative patients from blood banks and urban areas of Cameroon. Among HIV-1 positive samples, HHV-8 seropositivity rate was 61% based on combined reactivity using both ELISA and IFA techniques. HIV negative samples showed 62% seropositivity rate for HHV-8 antibodies. Our results indicate a high HHV-8 prevalence rate in both HIV infected and uninfected individuals in Cameroon.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Adult
Antibodies, Viral / immunology*
Cameroon / epidemiology
Enzyme-Linked Immunosorbent Assay
Female
HIV Infections / epidemiology*
HIV Infections / immunology*
HIV-1 / immunology*
HIV-1 / isolation & purification
Herpesviridae Infections / epidemiology*
Herpesviridae Infections / immunology*
Herpesvirus 8, Human / immunology*
Herpesvirus 8, Human / isolation & purification
Humans
Seroepidemiologic Studies

Substances

Antibodies, Viral