Five year outcomes of hypofractionated simultaneous integrated boost irradiation in breast conserving therapy; patterns of recurrence

Radiother Oncol. 2013 Aug;108(2):269-72. doi: 10.1016/j.radonc.2013.08.037. Epub 2013 Sep 19.

Abstract

In 2005, we introduced hypofractionated 3-dimensional conformal radiotherapy with a simultaneous integrated boost (3D-CRT-SIB) technique after breast conserving surgery. In a consecutive series of 752 consecutive female invasive breast cancer patients (stages I-III) the 5-year actuarial rate for local control was 98.9%. This new technique gives excellent 5-year local control.

Keywords: Breast conserving therapy; Local control; Radiotherapy; Simultaneous integrated boost.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Aged
  • Aged, 80 and over
  • Breast Neoplasms / mortality*
  • Breast Neoplasms / pathology
  • Breast Neoplasms / radiotherapy*
  • Breast Neoplasms / surgery
  • Cohort Studies
  • Combined Modality Therapy
  • Confidence Intervals
  • Disease-Free Survival
  • Dose Fractionation, Radiation
  • Female
  • Follow-Up Studies
  • Humans
  • Imaging, Three-Dimensional
  • Mastectomy, Segmental / methods
  • Middle Aged
  • Neoplasm Invasiveness / pathology
  • Neoplasm Recurrence, Local / mortality
  • Neoplasm Recurrence, Local / pathology*
  • Neoplasm Recurrence, Local / therapy
  • Neoplasm Staging
  • Netherlands
  • Radiotherapy Dosage
  • Radiotherapy, Adjuvant
  • Radiotherapy, Conformal / methods*
  • Retrospective Studies
  • Risk Assessment
  • Survival Analysis
  • Time Factors
  • Treatment Outcome